Abstract Background We report an extremely rare case of vaginal clear cell carcinoma. which originated from the malignant transformation of vaginal adenosis without prenatal diethylstilbestrol (DES) exposure. Case presentation In this case. the patient was a Chinese woman with a history of two decades of intermittent vaginal pain. https://www.roneverhart.com/Slate-Digital-VCC-Virtual-Console-Collection-p32717/