Abstract Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme environmental conditions. However. pharmacological induction of hypothermia in most mammals remains a huge challenge. Here we show that a natural product P57 promptly induces hypothermia and decreases energy expenditure in mice. https://safeersappliancers.shop/product-category/bosch-serie-6-pcs7a5b90-gas-hob-stainless-steel-lpg-convertible/